Analysts say the opioid epidemic started with the overprescription of legal pain medications in the 1990s, but it has intensified in recent years due to influxes of cheap heroin, fentanyl, and other synthetic opioids supplied by foreign drug cartels. The crisis has become a scourge on the economy, a threat to national security, and a major foreign policy challenge. Fentanyl and other opioids have fueled the worst drug crisis in U.S. history. In recent years, fatal overdose numbers have become defined by illicit fentanyl, an extremely lethal synthetic opioid, with more than two-thirds of overdoses being from this class of drug. Illegal fentanyl supplies are largely produced in China and Mexico and then smuggled into the United States. About Quest Diagnostics Workforce Health SolutionsThrough its workforce health solutions, Quest Diagnostics is a leading provider of laboratory testing and other services designed to optimize the health, safety, and wellbeing of employees.

Overdose Prevention
Duragesic® is used for pain severe enough to require around-the-clock pain relief for a long period of time. Speaking over the weekend on the Fox News program Sunday Morning Futures, House Speaker Mike Johnson suggested young men, who are highly vulnerable to drug addiction and account for the vast majority of U.S. overdose deaths, should not qualify for Medicaid insurance. Most drug policy experts say that funding helped reduce drug overdose deaths, which plunged 26.6% nationwide from June 2023 to October 2024, according to the latest provisional data from the Centers for Disease Control and Prevention. Another related complication of fentanyl overdoses includes the so-called wooden chest syndrome, which quickly induces complete respiratory failure by paralyzing the thoracic muscles, explained in more detail in the Muscle rigidity section below. Without the promise of new funding, many public health departments grappling with the deadly opioid-fentanyl crisis say they’ve already paused new spending. According to public health officials around the U.S., many addiction and drug overdose programs will reach the end of their current OD2A funding cycle by Sept. 1.
Law Enforcement Agencies Work The Case

The feds also shut down what prosecutors say were the Zheng’s 40 websites selling illegal drugs in 20 languages. We don’t know if their lab shut down, but the network has been, at least for now. Cronin’s investigators went online and discovered overseas labs offering most any illegal drug. Parents of several people who died after overdosing on fentanyl spoke at the event.
How Much Does Fentanyl Cost?
Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn baby. Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight. Do not use this medicine if you have used an MAO inhibitor (MAOI) (eg, isocarboxazid Marplan®, linezolid Zyvox®, phenelzine Nardil®, selegiline Eldepryl®, tranylcypromine Parnate®) within the past 14 days.
Sustained Recovery
While the dip marks the first reduction following three years of elevated positivity, the rate remains stubbornly high, with a 4% or higher overall drug positivity rate persisting over the past 10 years. This includes expanding access to treatment, harm reduction strategies, and interventions tailored to the hardest-hit states. While the paths to recovery can differ, understanding patterns of treatment, support services, and the duration of substance use offers valuable insights for helping others on their recovery journey. Discarded fentanyl patches may still contain significant amounts of the drug. This can result in misuse if someone removes the gel contents from discarded patches. As with other opioid drugs, fentanyl binds to the receptors in the brain that affect pain and emotion.
- People who experience trauma or abuse in the home may start using drugs as a coping mechanism.
- Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there.
- This helps visitors find and use information in the languages they speak, but the tool is not perfect.
- This robust pharmacologic agent is typically 50 to 100 times more potent.
- Additionally, if you choose a form of street fentanyl that comes in a predetermined amount – such as a pill or transdermal patch – there is no way to know the dosage it contains.
In US News
Portman and a bipartisan group of senators have actually introduced legislation to require the Postal Service to collect this electronic data. There are hurdles, including international treaties and the readiness or willingness of other countries to implement the same standards. But absent the passage of a bill — this plan has been introduced in previous Congresses too — lawmakers are pushing the Trump administration, particularly the State Department, to do more to bolster international shipping standards. A lot of experts would say that tackling demand and making treatment more accessible should be the top priority. Still, this new Senate report reveals in stunning detail just how easy it is to order some of the most potent opioids available from the other side of the world.
A small dose of fentanyl can be fatal depending on how tolerant someone is and their body size. Coroners’ offices and state crime laboratories do not test for fentanyl unless given a specific reason to do so. When someone with an opioid use disorder misuses fentanyl, it is usually illegally manufactured fentanyl rather than a prescription product. For example, the person may obtain it as powders or pills or add it to containers such as eyedroppers or nasal sprays. Street names for fentanyl include Apache, China Girl, Goodfellas, Great Bear, and Tango & Cash.
While the United States’ northern border sees far fewer fentanyl seizures, Canada has allocated an additional $900 million for border security and appointed a fentanyl czar. New combinations of synthetic opioids continue to crop up as well, complicating the crisis. Xylazine, a powerful chemical used in horse tranquilizers, and other novel opioids are reported to have far higher potency than pure fentanyl. The new report reveals changing patterns of drug use by the nation’s workforce. Random drug testing involves unscheduled and unannounced drug tests of employed individuals after they have presumably passed pre-employment drug screens.
Resources For People Who Use Drugs
Before entering any new agreement, they will withhold “cooperation as a piece of leverage” until they can extract “certain guarantees or the right price,” Amanda Hsiao, a director in the China practice at the political-risk consultancy Eurasia Group, told me. A fourth victim, Daniel Alejandro B.B., 21, was hospitalized in critical condition in intensive care, the attorney general’s office said. Witnesses at the scene told investigators that a fifth unidentified man was transported by his family to receive urgent medical care. The U.S. has sealed off the overseas bank accounts of Guanghua Zheng and his son.
Other Medical Problems

You will probably need to take a faster-acting opioid by mouth to relieve pain during the first few days of using fentanyl skin patch. You may also need another opioid while your dose of fentanyl is being adjusted, and to relieve any “breakthrough” pain that occurs later on. Be sure you do not take more of the other opioid, and do not take it more often than directed. Taking 2 opioids together can increase the chance of serious side effects. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.

Fentanyl has been temporarily assigned to the Schedule 1 category since 2018. Another concerning trend is the rise of fentanyl deaths in youths between ten and nineteen years old. Fatal fentanyl overdoses nearly doubled in teens between 2019 to 2021. Experts attribute some of this rise to the ease of purchasing counterfeit pills through social media. While this trend began to reverse in 2023, the rate remains high compared to pre-pandemic levels.
Illegal fentanyl, however, has an unknown amount of fentanyl and may be mixed with other drugs, which may result in harmful behaviors. Fentanyl use can result in death even with one dose, especially if a person accidentally takes it incorrectly. For continuous delivery, a transdermal patch can slowly deliver fentanyl through the skin and into the bloodstream for up to 72 hours. “As America is just now really starting to talk about fentanyl, we have now seen all these other substances that are popping up everywhere, and they’re coming out of these labs in China,” Maltz said.
One of the scariest factors of fentanyl addiction is that many people do not intend to take the drug or know that they are taking it. Unintentional fentanyl use is on the rise, as fentanyl is increasingly mixed with other drugs, like cocaine, heroin, xylazine, and methamphetamine, due to its strong effects and low cost of production. This is incredibly dangerous, as co-occurring drug use leads to a higher risk of overdose and death. Under the Biden administration, Congress and the federal government responded to escalating fentanyl deaths by ramping up spending on drug treatment and addiction health, including an expansion of the OD2A program.
Breakthrough Pain
I’ve sat in recovery meetings where people who once seemed beyond reach share stories of rebuilding their lives piece by piece. People exhibit increased hypervigilance, characterized by frequent perimeter-checking behavior and elevated startle response. Their psychological presentation includes persistent apprehension and surveillance of their environment, consistent with heightened threat perception. This crisis is not just a challenge; it’s a call to action that unites us all, from suburban neighborhoods to city streets, in a shared mission to build safer, healthier communities for everyone.